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On January 3, 2024, we announced that we will be accepting recommendations for potential new specialty measure sets or revisions to existing specialty measure sets for year 9 (CY 2017 performance period/2019 MIPS payment year through CY 2025 performance period/2027 MIPS payment year) of MIPS under the Quality Payment Program

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4 Dose-response and tissue-specific effects of metformin-mediated cardioprotection The cardioprotective efficacy of metformin is governed by its unique pharmacokinetic profile and a dose-dependent bifurcation in molecular signaling