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Estrogen impacts mitochondrial function through increasing oxidative phosphorylation, while at the same time decreasing mitochondrial superoxide production (Duckles et al., 2006

However, amidst these challenges, there are promising opportunities [101, 127]

Ethanol activates microglia, the resident immune cells in the brain, leading to chronic neuroinflammation characterized by the release of pro-inflammatory cytokines such as TNF- and IL-1

[36] Multiple sclerosis [edit] Multiple sclerosis (MS) is a chronic debilitating demyelinating disease of the central nervous system, caused by an autoimmune attack resulting in the progressive loss of myelin sheath on neuronal axons