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High concentrations of resveratrol may inhibit mitochondrial complex I, while synthetic activators like SRT2104 require high doses due to poor liver targeting, increasing oxidative stress risk in extrahepatic tissues

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sapidus within the Mediterranean basin, formed by both founder effects and secondary introductions

2.7 Metabolite analysis Online metabolite databases (KEGG, HMDB, PathBank) and the literature were used to link the statistically significant metabolites to metabolic pathways