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Postnatal mechanisms have been proposed, including immune dysregulation, gastrointestinal abnormalities, oxidative stress, and neural circuit differences, though these remain largely unproven and are the focus of ongoing research

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We conclude that zebrafish-centric platforms furnish a robust, mechanism-driven, and scalable framework to accelerate the discovery, mechanistic elucidation, and rational preclinical development of safer, multi-target phytotherapeutics, thereby catalyzing the evolution of plant-based medicine from empirical discovery to precision anti-inflammatory therapy guided by a systems-level, mechanism-driven paradigm