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[1] The majority of eicosanoids require arachidonic acid, which is cleaved from cell membranes by phospholipase A2 (PLA2) enzymes

10.4236/as.2014.513133 94 HusseinN

In the hypoxic TME, stabilization of HIF-1 not only enhances glycolytic flux through the upregulation of HK2 and PDPK1, but also supports tumor cell motility and invasiveness (77)