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European Heart J 2023

Thus since its inception, the somatomedin hypothesis has evolved to describe a more complex interplay between GH and IGF-1 (commonly referred to as the GH/IGF-1 axis) including negative feedback mechanisms where IGF-1 inhibits further GH production (Figure 2) [145]

It's important to understand that the iodine test does not provide a good indication of wort fermentability or extractionthe absence of starch does not mean that the mash is finished