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Acknowledgements The research group from CNR-ISAFoM acknowledges that part of this project was funded under the National Recovery and Resilience Plan (PNRR), Mission 4 Component 2 Investment 1.3-Call for proposal No

While effective in animal models, human data are limited to small case series [80]

Additionally, these studies also singled out the possibility that enhanced activity of glycolysis may have a bearing on exit from quiescence and HSC activation in at least some contexts [119], although the majority of literature has revealed that normal HSCs reside in a low-oxygen niche environment and their energy demands are highly dependent on the glycolytic pathway [122,123,124]

Funk CR, Wang S, Chen KZ, Waller A, Sharma A, Edgar CL, et al