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3.3 Immune system enhancement The natural substances can act as immune checkpoint and co-inhibitory modulators, some polyphenols decrease the expression of tissue-and tumoural PD-L1 or of CTLA-4 on T cells giving a mechanistic reasoning to combination with nutritional support in patients treated with check point inhibitors, eventually reversing acquired resistance to treatment or decreasing the effective dose for drug administration (193)

( Figure 1 ) and reddish streaks and striae on various parts of her body which were perpendicular to skin planes ( Figure 2 ), suggestive of possible bartonellosis

However, many studies have demonstrated that even in WT p53, the P72R SNP exerts an effect on its transcriptional regulation of target genes and subsequent activation of biological programs [16, 17, 22,23,24,25]

The interaction between ferroptosis and mitochondrial injury creates a synergistic effect, which exacerbates cardiac dysfunction during DCM progression (184)