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The most common musculoskeletal symptom was fatigue (133 [85.3%]), followed by myalgia (102 [68.0%]), arthralgia (65 [43.3%]) and back pain (33 [22.0%])

They are sometimes jokingly referred to as (first law), You cant get something for nothing, and (second law), You cant break even. The first law is based on the conservation of energy

The organism exhibits semi-autonomous genetic systems, independent genomes, and unique genetic codes that are similar to those found in bacteria (2)

For example, dysbiosis of the gut microbiota can lead to immune system dysfunction, reduce the immune response to tumors, and promote tumor growth and progression ( Figure 2 )