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Gonadectomy in male rats decreased CA1 spine synapse density compared to sham-operated animals (Jia et al., 2013)

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In still further preferred embodiments, the first solution consists essentially of a lipid chosen from Table 1, DSPC, Chol and PEG-DMG or PEG-cDMA, more preferably in a molar ratio of about 20-60% cationic lipid:5-25% DSPC:25-55% Chol:0.5-15% PEG-DMG or PEG-DMA

Additionally, always discard any reconstituted Semaglutide raw powder that has been stored outside refrigeration for more than a few hours, has exceeded the 28-day post-reconstitution period, or has been accidentally frozen, as these conditions compromise the medication's safety profile and therapeutic effectiveness