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Macrophage model has shown to be reliable predictor of mycobacterial infections ( MAP vaccines, and the use of the natural host model is strongly recommended

Exposure of recombinant CD38 + cells to isatuximab produced near-complete inhibition of the CD38 cyclase activity in a dose-dependent manner, while both a surrogate antibody for daratumumab (produced based on published sequences and thus potentially not completely identical to the original antibody) and daratumumab resulted in a much lower inhibition [19, 21, 22]

Additionally, our recent work demonstrates in real-time imaging assays that FAs can traffic from LDs to the nucleus to modulate gene expression in brown adipocytes (141)

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