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MOTS-c (short for Mitochondrial Open Reading Frame of the 12S rRNA type-c) is a peptide a short chain of amino acids that's encoded not in your nuclear DNA, but in your mitochondrial DNA

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Younossi 1,2,3 , Reem Al Shabeeb 4 , Katherine Elizabeth Eberly 4 , Dipam Shah 4 , Veronica Nguyen 1 , Janus Ong 5 , Saleh A Alqahtani 6 , Linda Henry 1,4,7 and Maria Stepanova 7 , (1)Betty and Guy Beatty Center for Integrated Research, Inova Health System, Falls Church, VA, (2)Center for Liver Disease, Department of Medicine, Inova Fairfax Medical Campus, Falls Church, VA, (3)Inova Medicine, Inova Health System, Falls Church, VA, (4)Inova Health Systems Medicine Service Line, Falls Church, VA, (5)College of Medicine, University of the Philippines, Manila, Philippines, (6)Johns Hopkins University School of Medicine, (7)Center for Outcomes Research in Liver Diseases, Washington, DC Background: High prevalence of obesity in the U.S