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To study the relevance of AKT-dependent effects we treated the cells with the specific AKT-inhibitor MK2206 ( Figure S2 ) to access the AKT-regulated antioxidant defense capacity upon IR in our AKT-WT and activated AKT-E17K mutant TrC1 isogenic cell line models

Insulin-like growth factor 1, but not growth hormone, has in vitro proliferative effects on neonatal foreskin fibroblasts without affecting 5-alpha-reductase or androgen receptor activity