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Because iron chelators such as deferoxamine (DFO) can block ferroptosis, ferroptosis was originally defined as iron-dependent

However, they typically require large, high-quality datasets and often suffer from limited interpretability

Low taurine conjugation to the tRNALeu(UUR) simply due to taurine content depletion in mitochondria results in the reduction of proteins that are essential in proper mitochondrial function NADH-ubiquinone oxidoreductase chains 5 and 6 (ND5 and ND6), critical components of complex I (Jong et al