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Consistent application over a period is required, often ranging from several weeks to a few months, before noticeable improvements in skin brightness, lightening of dark spots, and overall skin tone evenness can be observed

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Ganguly D, Jain CK, Chandra Santra R, Roychoudhury S, Majumder HK, Das S (2016) The biological in vitro effect and selectivity shown by a CoII complex of 2-(2-hydroxyphenylazo)-indole-3-acetic acid on three distinctly different cancer cells

Inclusion/exclusion criteria Studies were selected according to the following inclusion criteria: Original articles carried out on rodents of both sexes