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Allerdings ist die physikalisch-chemische Stabilitt dieser Peptide, beispielsweise in normaler Salzlsung, nicht zufrieden stellend

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The affinity of the rat amylin(2737) fragment with these mutations for amylin receptor 1 ECD binding ranged from pK I 6.61 to 7.53 (K I 29 nM to 243 nM) (Figure 7E, 7F and Table 2)