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10 , 614288 (2020) M.J

Interestingly, preclinical models have shown that curcumin can decrease the expression of Th1 cytokines (IL-12, IFN-gamma, TNF-alpha, IL-1) and increase the expression of Th2 cytokines (IL-4 and IL-10) in colon mucosa, promoting a shift from Th1 to Th2 [510]

Therefore, how to reasonably integrate various research findings and balance the differences under different experimental conditions is key to promoting the clinical application of silybin