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4d), indicating that part of the protective effect observed with NAC requires GSH synthesis

doi:10.1038/nrrheum.2010.43 77

Several neuropathological mechanisms supported both excitatory and synaptic dysfunction in ALS

It is encoded in the DLD gene localized to 7q31-q32 [61], its function is to catalyze the transfer of electrons from dihydrolipoamide to NAD+and bears close structural and functional approximation to the PDE3 component of pyruvate dehydrogenase and its full complex contains 6 dimers [5].Dihydrolipoamide dehydrogenase E3k The alphaketoglutarate dehydrogenase complex EC 1.2.4.2 also termed as oxoglutarate dehydrogenase complex, acts on alphaketo-glutarate/2 oxoglutarate a key intermediate in the krebs cycle converting to succinyl co A, produces NADH and CO2 in an irreversible reaction [62] KGDHC catalyzes a vital step in the Krebs cycle, which is also a step in the metabolism of the potentially excitotoxic neurotransmitter glutamate