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USA 119 , e2121385119 (2022)

From a translational perspective, these data motivate exploration of combination regimens (e.g., with thymoquinone or resveratrol) and evaluation in chronic/cumulative MTX paradigms where metabolic and apoptotic stress are sustained

The anatomical locations of these white-matter abnormalities are consistent with clinically observed impulsivity, affective reactivity, and aberrant processing of emotional stimuli (128131)