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Description

Intestinal permeability increases with age, allowing bacterial products into systemic circulation and driving inflammaging

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83,84 Multiple factors contribute to the accumulation and functional shaping of Tregs in the TME, including their activation and expansion by tumor-associated antigens (TAAs) presented by APCs

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reported that both L-lactate and D-lactate can inhibit HDACs, increasing the acetylation of histones H3 and H4, which enhances the DNA repair capacity of breast cancer cells and contributes to anticancer drug resistance

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