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Yoon WS, Chang JH, Kim JH, Kim YJ, Jung TY, Yoo H, et al

On the other hand, a recent meta-analysis showed significantly higher 6-TG levels among AIH in remission than those who failed to achieve remission [90]

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Furthermore, the redox system not only involves redox-associated enzymes, such as the glutathione biosynthesis pathway, GPXs, GR, catalase, superoxide dismutase (SOD), and NOXs, but also intertwines with glucose metabolism, fatty acid oxidation, and mitochondrial function for the generation of reducing equivalent NADPH, with glutamine metabolism for the supplement of glutamate for glutathione synthesis, and with other signaling pathways including NRF2-mediated upregulation of the antioxidant system for a better adaptation to oxidative stress