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JCI Insight (2021) 6(20):e151911

129 Melatonin, an over-the-counter drug for treatment of insomnia, appears to exert anti-inflammatory, antiapoptotic, and antioxidant effects

The food-derived glutathione levels within the protein-bound fraction between the plasma from the portal vein and from the inferior vena cava were insignificantly different, which indicates that glutathione in the low-molecular-weight fraction may be preferentially incorporated into the liver

Together, these limitations reveal a fundamental weakness in the translational pipeline: Preclinical models, often biologically reductionist and poorly representative of human pathology, remain inadequate to support the development of interventions with reproducible and clinically relevant neuroprotective effects