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Those patients that have complications that have been shown to be ameliorated by GLP-1-based drugs, and I would say secondary prevention of cardio, of heart attacks for semaglutide

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Furthermore, research has shown that fasting, CR, and caloric restriction mimetics (CRMs) can promote T-cell-mediated tumor cytotoxicity, alter NK cell function, and potentially trigger immunogenic cell death, thereby stimulating cancer immunosurveillance pathways