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All animal experiments were conducted in accordance with the ARRIVE guidelines and the U.K

This damage was closely tied to endothelial progenitor cell (EPC) dysfunction, as copper intake impaired EPC migration, tube formation, and adhesion, while markedly reducing phosphorylated eNOS and MnSOD levels, lowering nitric oxide (NO) production, and raising TSP-1 expressionultimately inhibiting angiogenesis (230232)

Table 1 demonstrates that imbalances in the gut microbiome can lead to various health issues within the gastrointestinal tract

Effect of Lactobacillus acidophilus and Bifidobacterium bifidum supplementation to standard triple therapy on Helicobacter pylori eradication and dynamic changes in intestinal flora