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FEBS Lett 366(23):151155

accordingly, a decrease in the activity of this enzyme complex initiates a cascade of unfavorable processes: depolarization of the mitochondrial membrane, calcium overload, and release of cytochrome c , which ultimately leads to cell death (Huang et al., 2003)

In 3xTg-AD neurons, rapamycin failed to affect free GTP levels, either because it was unable to stimulate autophagy or that the cells were able to handle the extra load and maintained GTP levels (Fig