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In ovarian cancer, three heterogeneous clusters (cluster 0, 3, and 4) emerged within HGSOC-1 and two clusters (cluster 1 and 2) in HGSOC-2 (Fig

However, given their high evidentiary power, RCTs remain valuable for establishing causal relationships following observational studies

Iddrisu Sulemana

It is worth mentioning that a recent study found that in tumors, the metabolite lactate affected the TME by regulating the lactylation of MOESIN in Tregs and enhancing TGF- signal transduction, thus promoting a new mechanism of tumorigenesis 266