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At the oxidative stress level, excessive generation of ROS and antioxidant system imbalance have been observed to not only directly damage intestinal mucosal cells but also to influence immune cell differentiation and barrier repair through modulation of signaling pathways, thereby creating a vicious cycle of inflammatory progression [12, 29]

Conjugated Linoleic Acid (CLA)

Published 2021

Folate supplementation in high-fructose-fed rats increased the phosphorylation levels of AMPK and LKB1 and inhibited the phosphorylation of ACCs in the liver, then significantly increases hepatic SAMe, inhibits hepatic lipogenesis and thus ameliorates hepatic steatosis (90)