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thus, the uptake, distribution, and elimination of Cu are tightly regulated

Colony-stimulating factors (rhG-CSF, rhGM-CSF, rhIL-3, and BCGF) recruit myeloblastic and lymphoblastic leukemic cells and enhance the cytotoxic effects of cytosine-arabinoside

It serves as a functional cofactor for lysyl oxidase (the enzyme that cross-links collagen fibers properly) and for superoxide dismutase (SOD1, a key antioxidant enzyme)