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found that overexpression of PGC-1 in muscle cells reduced oxidative stress and inflammation, suggesting that promoting mitochondrial biogenesis can have anti-inflammatory effects (St-Pierre et al., 2006)

However, given that CGRP can stimulate smooth muscle contraction in human airways [160], and has been implicated in mucus secretion in normal airways [142, 143], it is predicted that inhibition of CGRP might be of benefit in COPD