glutathion synthase ligase GLUTATHIONE SYNTHESIS γ-Glutamyl Cycle

Its advantages over GDNF include partial blood-brain barrier penetration capacity and independence from Ret signaling, overcoming the issue of Ret downregulation in advanced PD and making it an important complement to GFLs-based strategies

Se scavenges reactive oxygen species, protecting neurons from oxidative damage induced by nutrient imbalances (e.g., high sugar) (317)

Torres CM, Biran A, Burney MJ, Patel H, Henser-Brownhill T, Cohen AS, Li Y, Ben-Hamo R, Nye E, Spencer-Dene B, Chakravarty P, Efroni S, Matthews N, Misteli T, Meshorer E, Scaffidi P (2016) The linker histone H1.0 generates epigenetic and functional intratumor heterogeneity

Vitamin C also plays a critical role by helping to "recycle" used glutathione back into its active form