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vitamin E), enzymes that catalyze antioxidant reactions using NADPH as a source of reducing electrons and a liver microsomal cytochrome P-450 monooxygenase system, which also utilizes NADPH to convert steroids and drugs to soluble forms (Wu et al., 1989)

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Interestingly, the methylation of the FGF-21 gene declines prior to the onset of overt metabolic abnormalities, suggesting that this epigenetic change may represent an adaptive response by the liver to maintain glucose homeostasis during the early stages of metabolic dysregulation [216]