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If the ability to reduce GSSG to GSH is overwhelmed by a high burden of oxidative stress, GSSG can be exported out of cells or react with protein sulphydryl groups to prevent a major shift in the redox equilibrium [11], thereby depleting cellular GSH

Oxidant and antioxidant signalling in plants: A re-evaluation of the concept of oxidative stress in a physiological context

Section 4: Kidney Complication Codes, Required Companion Codes Whenever you use a diabetic nephropathy or CKD code, a second N18.x code is mandatory

At some point in time, these signaling cascades will eventually phosphorylate and promote the IKK complex