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Synergy determination with SynergyFinder The online SynergyFinder software ( was used to calculate drug synergy score with the inhibition index (the inhibition index = 100 - Cell Viability) by the response surface model and zero interaction potency (ZIP) calculation method

However, conventional 2D cell cultures lack a tissue structure (with a cellular organization and architecture established) and a development trajectory, these being some of the weaknesses compared to more complex models, such as organoids (Qian et al., 2019)