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This includes individuals with severe anxiety or other psychological disorders, thyroid dysfunction, cardiovascular disease, and those who are pregnant or breastfeeding

A 1994 in vivo study by Natera, Jiang, and Ng extended the observation into a whole animal, reporting that chronic administration of synthetic hGH 177 to 191 to genetically obese (ob/ob) mice was associated with reduced cumulative body-weight gain and reduced adipose mass relative to controls [2]

The effective potency could be a fraction of what the label states