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Based on the holistic structure and function of the organism, we further propose the framework of the gutbone axis plus X, which provides some reference for the derivation and qualification of the gutbone axis, helps to clinically interpret the gutbone axis stimulated by organs such as the brain and liver, and precisely facilitates the treatment of differentiated individuals with osteoporosis

However, long-term drug treatment can lead to a series of side effects, limiting their therapeutic effectiveness

intranasal application of nanocarbon may mitigate its practical application challenges due to dose-related CNS toxicity