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Mazdutide targets two receptors Mazdutide (IBI362) is a synthetic peptide related to mammalian oxyntomodulin

Hippocampal neurons were maintained in Neurobasal A media from Invitrogen (Carlsbad, CA) supplemented with B27 from Invitrogen, 0.5 raM L-glutamine, and 5mM cytosine-D-arabinofuranoside from Sigma added at 2 days in vitro

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This suggestion was further insisted as a potential mechanism of TB-500 by the authors of the research study, who also commented that " transfection of anti-miR-146a nucleotides reversed the inhibitory effect of T4 on IRAK1 and TRAF6