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The first hit involves dysregulated lipid metabolism leading to hepatocellular triglyceride accumulation, whereas the second hit encompasses oxidative stress and an amplified inflammatory response mediated by cytokines such as interleukins, transforming growth factor-1 (TGF-1), nuclear factor kappa B (NF-B), and tumor necrosis factor- (TNF-), ultimately predisposing to metabolic dysfunction-associated steatohepatitis (MASH), fibrosis, and cirrhosis 3

Table of Contents Toggle Overview of Glutathione Glutathione is a component produced naturally by the body out of three amino acids: glutamate, cysteine, and glycine

The effects of L-carnitine on NF-B p65 at the mRNA (Fig

By increasing the levels of PGC-1 and BCL2 and restoring the loss in ATP production, overexpression of PK2 restores mitochondrial biogenesis