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In turn, a low pH (about 1) causes a decrease in the intensity of the peak (Frassanitoa et al

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In addition to traditional oncogenic factors such as radiation, inflammation, and aging, MGs also exhibits significant genotoxicity ( 3.2 Histone modification Histone modifications play a central role in maintaining chromosome structure and regulating gene expression, serving as an important modality for epigenetic regulation ( 3.3 The cross-linking of MG stress, oxidative stress and chronic inflammation One of the key features of MG stress is the activation of RAGE, which triggers a series of signaling cascades that drive chronic inflammation and oxidative stress, thereby promoting tumor progression ( 3.3.1 MG stress and oxidative stress Imbalance in redox homeostasis is one of the hallmarks of cancer cells and can lead to malignant tumor progression and drug resistance ( 3.3.2 MG stress and chronic inflammation The role of chronic inflammation in cancer progression is well-established ( The crosstalk between chronic inflammation and oxidative stress has been well-established ( 3.4 Cellular proliferation and apoptosis One of the important mechanisms by which MG promotes tumor growth is through the regulation of signaling pathways involved in cell proliferation and apoptosis