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Frequent diarrhoea or urgency Blood or mucus in stool Abdominal cramping and pain Fatigue, weakness, and nutrient depletion Periods of remission followed by flares How Ozone Therapy May Help Ulcerative Colitis Research and clinical experience suggest ozone therapy may offer multiple supportive effects for some people with UC

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Beyond direct Nrf2 activators, other agents operate through complementary pathways: Glutamine alleviates injury by inhibiting the xanthine oxidase/uric acid axis[140], while compounds like agmatine and naringin exert their effects by enhancing cellular glutathione reserves and reducing lipid peroxidation[141, 142]