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FIGURE 2 Posttranslational oxidative modifications of certain proteins, such as ion channels, can result from imbalances in cellular redox state caused by ROS production, ineffective antioxidant defenses, or environmental oxidative stress

First isolated from human plasma in the early 1970s, it naturally occurs in blood, saliva, and urine but its concentrations decline sharply with age

In another study, high GGT levels were associated with marked endothelial dysfunction in patients with CKD, which suggests a link between elevated levels of this marker and the risk of cardiovascular disease.10 In addition to the possible systemic pro-oxidative effect, other hypotheses could help to explain the association between elevated GGT levels and mortality in patients with CKD

lf any discomfort occurs, discontinue use and consult a doctor