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Of course, this is just a preliminary measurement on a few subjects, the aim of which is to underline the possibility of enhancing the differences in the contribution between extra- and intra-cerebral blood flow signals, rather than to give a physiological conclusion

This review aims to summarize (i) the different pathways to cross the BBB, (ii) the strategies that can be employed to increase nanoparticle BBB permeation without disrupting the BBB, as well as (iii) the different nanoparticle types that can be used for drug delivery across the BBB

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