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(ii) copper-induced ROS formation and the oxidative modification of low-density lipoprotein cholesterol facilitate the development of atherosclerotic plaques (El-Hajjar et al., 2022[129])

Brain Pathol 3(4):405412 Friedman LK, Pellegrini-Giampietro DE, Sperber EF et al (1994) Kainate-induced status epilepticus alters glutamate and GABAA receptor gene expression in adult rat hippocampus: an in situ hybridization study [J]

Nevertheless, it should not be underestimated that some strains can produce bitter peptides that negatively affect the taste of the fermented product

Another randomized controlled trial showed that adding Bevacizumab to fluorouracil and leucovorin improved PFS in patients with mCRC for whom first-line irinotecan was judged inappropriate due to their poor functional status [81]