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In pregnant rabbits given once weekly subcutaneous doses of 0.01, 0.03, or 0.1 mg/kg tirzepatide (0.01-, 0.06-, and 0.2-fold the MRHD) during organogenesis, pharmacologically mediated effects on the gastrointestinal system resulting in maternal mortality or abortion in a few rabbits occurred at all dose levels

1997 Aug;282(2):845-50

Vitamin C-sources, physiological role, kinetics, deficiency, use, toxicity, and determination

If you are taking medications or supplements to lower your blood pressure, speak to your healthcare professional about the necessity of changing doses and acceptable doses for supplementing Vitamin B1