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PLoS One 9(12):e116565

Activation of these TLRs triggers the NF-B and mitogen-activated protein kinase (MAPK) pathways, leading to the production of proinflammatory cytokines (TNF-, IL-6, IL-1) and chemokines (CXCL-1, CXCL-2) (Wang et al., 2019)

Rights and permissions About this article Cite this article Songire, V.M., Patil, R.H

While the exact mechanisms are still being unraveled, functional medicine practitioners and researchers are increasingly looking at pre-existing toxic burdensspecifically heavy metal accumulationas a critical piece of the puzzle