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A key feature of the cellular response to hypoxia was the intracellular distribution of the mitochondrial network, which contributed to hypoxic signaling via HIF activation and was regulated by cross-talk between CHCHD4 and HIF-1

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The cytosolic O-acetylserine(thiol)lyase gene is regulated by heavy metals and can function in cadmium tolerance

(Sub)total surgical removal of the colon in people with colorectal cancer (without PSC) resulted in a significant reduction of TMAO compared with hemicolectomy, while surgery-related changes for other biomarkers suggested they primarily originated from outside the gut