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In addition, a case report study on a duodenum biopsy reported an increase in p-gp expression of greater than twofold in a CD patient, as compared with healthy specimens [109]

Although multiple studies have successfully used coimmunoprecipitation and mass spectrometry to identify binding partners in iron trafficking pathways, the transient and weak nature of these interactions may prevent the co-purification of protein complexes

In a large cohort study, nearly all cases of initial thyrotoxicosis evolved late hypothyroidism, with overt thyrotoxicosis occurring a median of 5 weeks after the first ICI dose and overt hypothyroidism developing a median of 14 weeks later (Muir et al

These RATs were divided into five groups with n = 7