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Do the math: it's more than 5000 years definitely an oldie

10.1016/j.molcel.2017.09.009 Mol

Malnourishment, eating disorders, and cachexia (muscle wasting) can also increase the risk of liver injury following overdose (Ferner 2011)

Proteomic analyses confirmed enrichment of ER and autophagy pathways, and pharmacological inhibition of ER stress alleviated autophagic dysfunction and cellular injury, supporting a causal role for ER perturbation in cardiomyocyte toxicity [28, 161]