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To calculate a comparable dosage to apply in clinical settings, researchers may refer to the dose conversion guidelines established by Nair et al

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Avoiding Certain Activities: Refrain from engaging in activities that could potentially irritate or damage the skin, such as swimming in chlorinated pools, using hot tubs, or undergoing other cosmetic treatments, for at least 48 hours post-treatment

An optimal protocol should incorporate stratified randomization based on OS biomarker profiles (e.g., plasma MDA, urinary 8-OHdG) to identify subgroups most likely to benefit