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This regulatory function of the androgen receptor ligand binding domain in the absence of hormone, is not unique for the androgen receptor and has been reported also for the glucocorticoid receptor (155)

2003;133(11):3886S3892S

In a 2010 European study, sponsored by the manufacturer of Prilactone, the investigators reported that spironolactone, when added to conventional cardiac therapy (such as an ACE-inhibitor, plus furosemide and digoxin if needed ) was found to decrease the risk of reaching the primary endpoint (ie, cardiac-related death, euthanasia, or severe worsening) in dogs with moderate to severe mitral regurgitation caused by MVD

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