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From a safety perspective, although international regulatory bodies, such as the EFSA and WHO, have confirmed its safety within the recommended dosage range, some studies have suggested that long-term or high-dose intake may pose potential risks, including immune dysregulation, reproductive toxicity, and hepatic or renal metabolic burdens

Nrf2 activation attenuates oxidative stress by inducing anti-oxidant enzymes (e.g., HO-1, NQO1) which in turn reduce ROS levels

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10.1126/science.aaw7567 146 TancharoenW.AungsuchawanS.PothacharoenP.BumroongkitK.PuanintaC.PangjaideeN.et al (2019)